Author

C. Icke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. F. Cunningham· 5 shared I. R. Henderson· 4 shared J. A. Bryant· 4 shared J. A. Cole· 3 shared E. Heinz· 2 shared J. Rooke· 2 shared K. Pullela· 2 shared S. S. Chng· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersMicrobiology

A. F. Cunningham

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Author profile →

5 papers

Recent·Most cited

Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

J. Gray, V. V. L. Torres, E. C. Goodall, S. A. McKeand, D. Scales, C. Collins, L. Wetherall, Z. J. Lian, J. A. Bryant, M. T. Milner, K. Dunne, C. Icke, J. Rooke, T. Schneiders, P. A. Lund, , I. R. Henderson

This study identifies essential genes for Klebsiella pneumoniae growth in human urine and serum using transposon mutagenesis, highlighting potential antimicrobial targets.

bioRxiv · May 31, 2023Microbiology

YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth.

E. C. A. Goodall, G. L. Isom, J. L. Rooke, C. Icke, K. Pullela, B. Zhang, J. Rae, W. B. Tan, M. Winkle, A. Delhaye, E. Heinz, J.-F. Collet, A. F. Cunningham, M. A. Blaskovich, R. G. Parton, , I. R. Henderson

This study identifies YhcB as a coordinator of peptidoglycan, LPS, and phospholipid synthesis in E. coli, revealing its role in envelope stability and cell size control.

bioRxiv · Apr 16, 2021Microbiology

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

C. Icke, F. Hodges, K. Pullela, S. McKeand, J. A. Bryant, A. F. Cunningham, J. A. Cole, I. R. Henderson

The paper identifies a new bacterial secretion system, Aat, that acylates a lipoprotein, CexE, on a glycine residue instead of the typical cysteine, leading to surface display of the protein.

bioRxiv · Sep 23, 2020Microbiology

BamA and BamD are essential for the secretion of trimeric autotransporter adhesins

J. Rooke, C. Icke, T. J. Wells, A. E. Rossiter, D. F. Browning, F. C. Morris, J. Leo, M. S. Schuetz, I. B. Autenrieth, A. F. Cunningham, D. Linke, I. R. Henderson

This study shows that BamA and BamD are essential for secreting trimeric autotransporters, while BamB, C, E, TamA, and TamB are not required for this process.

bioRxiv · Aug 14, 2020Microbiology

Structure-function analyses of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation

J. A. Bryant, F. Morris, T. J. Knowles, R. Maderbocus, E. Heinz, G. Boelter, D. Alodaini, A. Colyer, P. wotherspoon, K. Staunton, M. Jeeves, D. Browning, Y. Sevastsyanovich, T. Wells, A. Rossiter, , i. henderson

This study identifies phospholipid binding as a mechanism for DolP localization, revealing its structure and function in Gram-negative bacteria.

bioRxiv · Aug 10, 2020 · PreprintBiochemistry