I. R. Henderson

The paper identifies that a high IgG2:IgG3 antibody ratio inhibits complement-mediated killing of Neisseria gonorrhoeae, revealing a mechanism for bacterial resistance.

The paper identifies synthetic-lethal interactions of Bam complex associated genes in E. coli, revealing dependencies on lipid composition and peptidoglycan synthesis.

This study identifies essential genes for Klebsiella pneumoniae growth in human urine and serum using transposon mutagenesis, highlighting potential antimicrobial targets.

This study shows that Salmonella infection disrupts follicular dendritic cell networks and prevents germinal center formation in the spleen.

This study compares the efficacy of Vi polysaccharide and conjugated Vi vaccines in protecting against Salmonella Typhi, finding that conjugated vaccines sustain immune responses better over time.

The paper uses machine learning to identify key chromatin features that determine meiotic recombination sites in plants, finding that three features can predict crossover sites with 90% accuracy.

This study identifies HSBP as a repressor of HEI10 transcription and meiotic crossovers in Arabidopsis by binding to HSFs and maintaining DNA methylation at the HEI10 promoter.

This study identifies DpaA as an amidase that detaches Braun's lipoprotein from peptidoglycan in E. coli, revealing dynamic regulation of the cell envelope under stress.

This study identifies YhcB as a coordinator of peptidoglycan, LPS, and phospholipid synthesis in E. coli, revealing its role in envelope stability and cell size control.

This study attempts to increase crossover frequency in Arabidopsis by targeting a recombination hotspot with CRISPR-dCas9-MTOPVIB but finds no significant change in crossover frequency or pattern.

The paper identifies a new bacterial secretion system, Aat, that acylates a lipoprotein, CexE, on a glycine residue instead of the typical cysteine, leading to surface display of the protein.

This study shows that BamA and BamD are essential for secreting trimeric autotransporters, while BamB, C, E, TamA, and TamB are not required for this process.

The paper presents the crystal structure of E. coli BepA, an M48 metalloprotease, and shows that its active site plug regulates function and is conserved across the family.

This study identifies iron as a ligand for SecA-like metal-binding domains in E. coli, showing that these domains bind iron preferentially and that azide disrupts this interaction.

DeepTetrad uses deep learning to analyze pollen tetrads and measure crossover frequency and interference in Arabidopsis plants.