A. F. Cunningham

Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection

This study identifies discrete inflammatory signatures driving thrombosis in the spleen and liver after Salmonella infection, revealing both organ-specific and shared mechanisms.

Different vaccine platforms result in distinct antibody responses to the same antigen in haemodialysis patients

This study compares antibody responses in haemodialysis patients after vaccination with different platforms, finding mRNA vaccines induce better functional responses than viral vectors.

Inhibition of Neisseria gonorrhoeae complement-mediated killing during acute gonorrhoea is dependent upon the IgG2:IgG3 antibody ratio

The paper identifies that a high IgG2:IgG3 antibody ratio inhibits complement-mediated killing of Neisseria gonorrhoeae, revealing a mechanism for bacterial resistance.

Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

This study identifies essential genes for Klebsiella pneumoniae growth in human urine and serum using transposon mutagenesis, highlighting potential antimicrobial targets.

Salmonella infection induces the reorganisation of follicular dendritic cell networks concomitant with the failure to generate germinal centres

This study shows that Salmonella infection disrupts follicular dendritic cell networks and prevents germinal center formation in the spleen.

Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses

This study compares the efficacy of Vi polysaccharide and conjugated Vi vaccines in protecting against Salmonella Typhi, finding that conjugated vaccines sustain immune responses better over time.

YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth.

This study identifies YhcB as a coordinator of peptidoglycan, LPS, and phospholipid synthesis in E. coli, revealing its role in envelope stability and cell size control.

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

The paper identifies a new bacterial secretion system, Aat, that acylates a lipoprotein, CexE, on a glycine residue instead of the typical cysteine, leading to surface display of the protein.

BamA and BamD are essential for the secretion of trimeric autotransporter adhesins

This study shows that BamA and BamD are essential for secreting trimeric autotransporters, while BamB, C, E, TamA, and TamB are not required for this process.

Structure-function analyses of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation

This study identifies phospholipid binding as a mechanism for DolP localization, revealing its structure and function in Gram-negative bacteria.

Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48 metalloprotease BepA

The paper presents the crystal structure of E. coli BepA, an M48 metalloprotease, and shows that its active site plug regulates function and is conserved across the family.

Structure-function analysis of the Escherichia coli β-barrel assembly enhancing protease BepA suggests a role for a self-inhibitory state

This study presents the crystal structure of BepA, a protease involved in LptD folding, and shows its auto-regulation and role in maintaining outer membrane lipid asymmetry.