J. Gray

Dietary iron deficiency impairs effector function of memory T cells following influenza infection

This study shows that dietary iron deficiency impairs memory T cell function after influenza infection, specifically reducing IFN-gamma production without recovery through dendritic cell co-culture.

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns

This study identifies microbiota-derived inosine as a key factor in promoting CD8+ T cell responses against influenza in newborns by reversing epigenetic dysregulation.

Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis

This study identifies dynamic chromatin accessibility changes during osteosarcoma metastasis to the lung, revealing epigenetic states critical for metastatic colonization and new therapeutic targets.

Genome-wide synthetic-lethality screen of Bam complex associated genes in Escherichia coli

The paper identifies synthetic-lethal interactions of Bam complex associated genes in E. coli, revealing dependencies on lipid composition and peptidoglycan synthesis.

Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

This study identifies essential genes for Klebsiella pneumoniae growth in human urine and serum using transposon mutagenesis, highlighting potential antimicrobial targets.

The Evolution of Centriole Degradation in Mouse Sperm

This paper investigates how sperm centrioles evolved to become dispensable in mice by analyzing changes in the FAM161A protein and centriole structure across rodent species.

Integrative transcriptomic and proteomic meta-analysis of Zika viral infection reveals potential mechanisms for oncolytic therapy in neuroblastoma

This study identifies molecular mechanisms of Zika virus-induced oncolysis in neuroblastoma and highlights a promising oncolytic virotherapy candidate.

Distinct tumor-immune ecologies in NSCLC patients predict progression and define a clinical biomarker of therapy response

The paper analyzes multiplexed histological images from NSCLC patients to identify spatial immune ecologies that predict disease progression and serve as potential biomarkers for therapy response.

Peptidoglycan recycling contributes to outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii

This study identifies peptidoglycan recycling as a mechanism contributing to outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii.

Balance between protective and pathogenic immune responses to pneumonia in the neonatal lung enforced by gut microbiota.

The paper shows that gut microbiota balance immune responses in neonatal lungs, promoting recovery from pneumonia by modulating tissue repair and inflammation.

A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation

This study investigates the fetal lung immune response to intra-uterine inflammation in Rhesus macaques, finding a rapid myeloid cell activation and cytokine-driven inflammation.

DpaA detaches Braun's lipoprotein from peptidoglycan

This study identifies DpaA as an amidase that detaches Braun's lipoprotein from peptidoglycan in E. coli, revealing dynamic regulation of the cell envelope under stress.

Four-dimensional characterization of the Babesia divergens asexual life cycle: from the trophozoite to the multiparasite stage

This paper uses 3D and 4D imaging to characterize the asexual life cycle of Babesia divergens, revealing the origin and dynamics of its intraerythrocytic forms.

First detection of Infectious Spleen and kidney Necrosis Virus (ISKNV) associated with massive mortalities in farmed tilapia in Africa

This study identifies Infectious Spleen and Kidney Necrosis Virus (ISKNV) as the cause of high mortality in farmed tilapia in Lake Volta, Ghana, and shows its widespread presence across multiple farms.

Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare

Acinetobacter baumannii incorporates D-Lysine into its peptidoglycan to gain immunity against T6SS attacks from competitors, though this trait is lost in pathogenic strains due to host enzyme activity.

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.

Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

The paper identifies cytoskeletal proteins that regulate cell wall synthesis in Helicobacter pylori, linking their distribution to specific Gaussian curvatures that maintain helical shape.

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

The paper identifies key factors distinguishing non-toxic and toxic compounds targeting mitochondria in cancer therapy using SAR studies and a mathematical model.