Exosomes and exosomal miRNAs from muscle-derived fibroblasts promote skeletal muscle fibrosis
M. Mora, S. Zanotti, S. Gibertini, F. Blasevich, C. Bragato, S. Saredi, C. Introna, P. Bernasconi, L. Maggi, R. Mantegazza
This study shows that exosomes from DMD fibroblasts promote fibrosis by transferring miR-199a-5p, which reduces caveolin-1 and activates fibroblast-to-myofibroblast conversion.
bioRxiv · Feb 19, 2018Pathology