Cell BiologyLife Science AlliancePeer-reviewed
A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
E. Rusilowicz-Jones, J. Jardine, A. Kallinos…·M. J. Clague
The paper identifies a USP30 inhibitor that mimics genetic loss of USP30, revealing its role in regulating mitochondrial ubiquitylation and mitophagy through TOM complex components.
DOI 10.26508/lsa.202000768