A. Martinez

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.

Rational design of disordered proteins for systematic sequence-to-function investigation

This paper introduces GOOSE, a computational framework for designing intrinsically disordered proteins, and demonstrates its ability to create IDRs with specific functional responses.

Drivers of species knowledge across the Tree of Life

The paper examines factors influencing biodiversity knowledge distribution, finding socio-cultural traits and species characteristics drive scientific and societal interest.

Microplastics found in Antarctic penguins: chemical reactivity theory to analyze possible toxicity

The paper uses quantum chemistry to compare the reactivity of polyester and polyethylene oligomers, finding polyester more toxic due to its oxidizing properties and ability to disrupt DNA.

On the quest for novelty in ecology

This study analyzes the use of novelty terms in ecological research abstracts and finds an increasing trend associated with higher citations and impact factors.

Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY

The paper identifies a core genome of nucleus-forming bacteriophages and characterizes the replication mechanism of Erwinia phage RAY.

USP8 inhibition promotes Parkin-independent mitophagy in the Drosophila brain and in human neurons

This study shows that USP8 inhibition increases Parkin-independent mitophagy in Drosophila and human neurons by reducing USP8 levels, suggesting a new mitophagic pathway.

Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma

The paper introduces PROSPERO, a single-cell assay to evaluate therapy response in glioblastoma by measuring molecular drug responses in fresh tumor samples, revealing limited therapeutic capacity and cellular plasticity.

Bordetella spp. block eosinophil recruitment to suppress lung iBALT formation

This study shows Bordetella spp. block eosinophil recruitment to prevent iBALT formation, which suppresses immune responses and promotes bacterial persistence.

Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development

This study shows that sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development, with male-specific macrophage responses driving tumour regression.

Joint effect of temperature and insect chitosan on the heat resistance of Bacillus cereus spores in rice derivatives

The study examines how insect chitosan affects the heat resistance of Bacillus cereus spores in rice substrates, finding that chitosan increases heat resistance and alters z values.

Climate change will redefine taxonomic, functional, and phylogenetic diversity patterns of Odonata in space and time

This study predicts how climate change will alter taxonomic, functional, and phylogenetic diversity of European Odonata, identifying body size and flight period as key traits influencing range shifts.

Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation

This study shows that loss of SENP2 causes adrenal cortex zonal defects and glucocorticoid deficiency by disrupting transdifferentiation and signaling pathways.

Steroidogenic factor-1 lineage origin of skin lesions in Carney complex syndrome

This study identifies dermal fibroblasts as the origin of skin lesions in Carney complex by showing their pro-melanogenic activity under PKA signaling disruption.

An oral protein cocktail therapeutic for C. difficile infection

This paper describes an oral protein cocktail, LMN-201, for C. difficile infection, showing it achieves high cure rates and validates spirulina as a delivery platform.

High-affinity nanobodies as tools for structural and functional studies on mammalian Arc

This study produces and characterizes high-affinity anti-Arc nanobodies, revealing structural dynamics of Arc CTD and its role in oligomerization and capsid formation.

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima, Peru

The paper tests domestic cats in Lima, Peru for SARS-CoV-2 neutralizing antibodies, finding 17.1% and 31.7% positive rates using two cutoffs.

Meiofauna is an important, yet neglected, component of biodiversity of Posidonia oceanica

The paper reviews meiofaunal diversity in Posidonia oceanica meadows, identifies key environmental drivers, and highlights the potential for future research on meiofauna in this ecosystem.

Mobile microscopy and telemedicine platform assisted by deep learning for quantification of Trichuris trichiura infection.

This paper presents a mobile microscopy and telemedicine platform with deep learning for automated quantification of Trichuris trichiura infection, achieving high precision and recall in stool sample analysis.

PKA drives paracrine crisis and WNT4-dependent testis tumor in Carney complex

The paper investigates the role of PKA in Carney complex testis tumors, showing that Prkar1a mutations in both stromal and Sertoli cells drive LCCSCTs via WNT4-dependent paracrine signaling.

Identification of NPC1 as a novel SARS-CoV-2 intracellular target

The paper identifies NPC1 as a novel SARS-CoV-2 intracellular target, showing its interaction with the viral nucleoprotein and its inhibition by small molecules that also block EBOV entry.

Macrocybin, a mushroom natural triglyceride, reduces tumor growth in vitro and in vivo through caveolin-mediated interference with the actin cytoskeleton

This study identifies Macrocybin, a mushroom-derived triglyceride, as an antitumor compound that inhibits tumor growth by disrupting the actin cytoskeleton via caveolin-1 upregulation.

Host-directed FDA-approved drugs with antiviral activity against SARS-CoV-2 identified by hierarchical in silico/in vitro screening methods

The paper identifies five FDA-approved drugs with antiviral activity against SARS-CoV-2 using a combined in silico and in vitro screening approach.

Evolutionary analysis of SARS-CoV-2 spike protein for its different clades

This study analyzes the evolutionary patterns of SARS-CoV-2 spike protein across seven clades, identifying haplotype diversity and similar evolutionary rates across clades.

Habitat differences filter functional diversity of low dispersive microscopic animals

The paper examines how habitat differences influence functional diversity in marine mite communities across sea-grass meadow habitats, finding that habitat filters traits but has limited impact on species abundance.

Specialized terminology limits the reach of new scientific knowledge

This study shows that using jargon in paper titles and abstracts reduces citations, suggesting scientists should limit jargon to unavoidable sections.

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

The paper identifies a USP30 inhibitor that mimics genetic loss of USP30, revealing its role in regulating mitochondrial ubiquitylation and mitophagy through TOM complex components.

Scientometric correlates of high-quality reference lists in ecological papers

The paper analyzes reference list characteristics of ecological papers to identify factors correlating with citation impact.

Molecular determinants of Arc oligomerization and formation of virus-like capsids

This paper identifies a 28-amino-acid region in Arc critical for oligomerization and virus-like capsid formation, showing that exogenous RNA enhances assembly.

Cognitive and non-cognitive outcomes associated with student engagement in a novel brain chemoarchitecture mapping and connectomics course-based undergraduate research experience

This study evaluates a CURE course on brain mapping, finding it improves student skills, science identity, and produces valid scientific outputs in neuroanatomy.