M. J. Clague

The paper identifies TRIM3 as a novel microtubule-binding protein using differential extraction proteomics and shows its role in acetylated tubulin accumulation.

The paper investigates CTLA4 turnover, showing ubiquitylation at K203 and K213 drives lysosomal degradation, with USP8 and HD-PTP modulating this process through distinct mechanisms.

This study shows that the VPS35 D620N mutation enhances LRRK2 activity and amplifies its response to endolysosomal stress, leading to increased phosphorylation of RAB10 and RAB12.

This study uses Drosophila models to analyze pexophagy across tissues, showing tissue-specific regulation and identifying Hsc70-5 as a key regulator in neurons.

This study shows USP18 suppresses ISG15 E1 enzyme expression and cell growth inhibition in interferon-stimulated cells independently of its deubiquitylase activity.

The paper identifies MLN4924 and CMPD-39 as activators of pexophagy, showing distinct pathways mediated by BNIP3L/NIX and NBR1 respectively.

This study identifies FBXL4 as a negative regulator of basal mitophagy through NIX stabilization, showing that its deficiency promotes mitophagy and suggesting MLN4924 as a potential therapeutic agent for mitochondrial diseases.

This study identifies USP31 as a deubiquitylase regulating the chromosomal passenger complex and spindle dynamics during mitosis, leading to chromosomal segregation errors and polyploidy upon depletion.

This paper benchmarks a selective USP30 inhibitor, compound 39, showing it enhances mitophagy and pexophagy in cell models.

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

The paper identifies a USP30 inhibitor that mimics genetic loss of USP30, revealing its role in regulating mitochondrial ubiquitylation and mitophagy through TOM complex components.

This study identifies USP9X as a deubiquitylase that regulates ZNF598 stability, impacting ribosomal quality control through modulation of di-ribosome resolution.

The paper investigates the role of PINK1 and parkin in basal mitophagy in Drosophila, finding no significant impact on basal mitophagy despite locomotor defects and dopaminergic neuron loss.