Cancer BiologybioRxiv
USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
E. J. Ruiz, A. Pinto-Fernandez, A. P. Turnbull…·A. Behrens
This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.