Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment
Y. Huang, C. J. Garcia Garcia, D. Lin, N. D. Nguyen, T. N. Fujimoto, J. Zhao, J. J. Lee, V. Bernard, M. Yu, A. M. Delahoussaye, J. L. Phan, A. Deorukhkar, J. M. Molkentine, N. R. Fuentes, M. C. Turner, , C. M. Taniguchi
This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.
bioRxiv · May 21, 2021 · PreprintCancer Biology