Author

C. J. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. A. Doudna· 2 shared B. A. Adler· 1 shared D. Karandur· 1 shared I. P. Witte· 1 shared J. C. Cofsky· 1 shared J. Kuriyan· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

J. A. Doudna

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2 papers

Recent·Most cited

BiochemistrybioRxivDec 6, 2021

A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression

C. J. Huang, B. A. Adler, J. A. Doudna

This paper shows that CRISPR-Cas12c provides antiviral immunity by binding DNA without cleaving it, enabling transcriptional repression and phage protection.

DOI 10.1016/j.molcel.2022.04.020

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

BiochemistrybioRxivFeb 10, 2020

CRISPR-Cas12a exploits R-loop asymmetry to form double strand breaks

J. C. Cofsky, D. Karandur, C. J. Huang…·J. A. Doudna

This study shows that Cas12a uses R-loop asymmetry to cut the second DNA strand without direct protein interaction, explaining its double-strand break mechanism.

DOI 10.7554/elife.55143

DNA methylationproteomics

𝕏 PostBluesky