Author

C. J. Serpell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. R. Paul· 1 shared B. Claringbold· 1 shared C. M. Wischik· 1 shared L. C. Serpell· 1 shared L. Lutter· 1 shared M. D. Garrett· 1 shared M. F. Tuite· 1 shared S. Vance· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. R. Paul

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Author profile →

2 papers

Recent·Most cited

Sequence-defined oligophosphoesters for selective inhibition of the KRAS G12D/RAF1 interaction

B. Claringbold, S. Vance, A. R. Paul, M. D. Garrett, C. J. Serpell

The paper develops sequence-defined oligophosphoesters to inhibit the KRAS G12D/RAF1 interaction, achieving low IC50 values and selectivity for the mutant form.

bioRxiv · Mar 12, 2024 · PreprintCancer Biology

Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic force microscopy image analysis

L. Lutter, Y. Al-Hilaly, C. J. Serpell, M. F. Tuite, C. M. Wischik, L. C. Serpell, W.-F. Xue

This paper develops a method to identify individual amyloid fibril structures using AFM with cryo-EM maps, showing dGAE fibrils are structurally distinct from heparin-induced tau fibrils and related to Alzheimer's PHFs.

bioRxiv · Oct 19, 2021Biophysics