L. Lutter

Structural reconstruction of individual filaments in Abeta42 fibril populations assembled in vitro reveal rare species that resemble ex vivo amyloid polymorphs from human brains

The paper uses atomic force microscopy and cryo-electron microscopy to analyze Aβ42 fibril structures in vitro, identifying rare polymorphs similar to those found in human brain amyloid.

Compartment-driven imprinting of intestinal CD4 (regulatory) T cells in inflammatory bowel disease and homeostasis

The paper examines CD4 T cell changes in inflammatory bowel disease, finding compartment-specific transcriptional programming driven by regulators like ARID4B and SATB1, with epithelial translocation dampening pro-inflammatory responses.

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

This study identifies functional heterogeneity in human regulatory T-cells within inflamed arthritic joints using single-cell sequencing and flow cytometry.

Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic force microscopy image analysis

This paper develops a method to identify individual amyloid fibril structures using AFM with cryo-EM maps, showing dGAE fibrils are structurally distinct from heparin-induced tau fibrils and related to Alzheimer's PHFs.

Catestatin regulates the colonic mucus layer in inflammatory bowel disease

This study shows that catestatin (CST) regulates the colonic mucus layer in IBD, with CST levels elevated in IBD patients and CST-KO mice showing increased mucus thickness.

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

The paper identifies a conserved human effector Treg signature through transcriptomic and epigenetic analysis, showing overlap with tumor-infiltrating Treg and environment-driven adaptations.

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

Three-dimensional reconstruction of individual helical nano-filament structures from atomic force microscopy topographs

This paper demonstrates a method to reconstruct 3D structures of individual helical nano-filaments from AFM topographs by using contact-point based deconvolution to overcome tip-sample convolution effects.

Quantification of amyloid fibril polymorphism by nano-morphometry reveals the individuality of filament assembly

This study quantifies amyloid fibril polymorphism using nano-morphometry and AFM, revealing structural heterogeneity and its implications for amyloid assembly and disease.

Antigen-driven PD1+Tox+Eomes+ and PD1+Tox+BHLHE40+ synovial T lymphocytes regulate chronic inflammation in situ

The paper identifies distinct subpopulations of synovial T lymphocytes in JIA patients using single-cell RNA-sequencing and shows their roles in regulating chronic inflammation.