Author

M. D. Garrett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

H. D. Thomas· 2 shared H. Sellier· 2 shared I. Collins· 2 shared J. A. Butterworth· 2 shared J. E. Hunter· 2 shared N. D. Perkins· 2 shared S. Luli· 2 shared A. E. Campbell· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

H. D. Thomas

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3 papers

Recent·Most cited

Sequence-defined oligophosphoesters for selective inhibition of the KRAS G12D/RAF1 interaction

B. Claringbold, S. Vance, A. R. Paul, M. D. Garrett, C. J. Serpell

The paper develops sequence-defined oligophosphoesters to inhibit the KRAS G12D/RAF1 interaction, achieving low IC50 values and selectivity for the mutant form.

bioRxiv · Mar 12, 2024 · PreprintCancer Biology

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

J. E. Hunter, A. E. Campbell, N. L. Hannaway, S. Kerridge, S. Luli, J. A. Butterworth, H. Sellier, R. Mukherjee, H. D. Thomas, P. J. Brownridge, J. Coxhead, L. Taylor, P. Leary, M. S. R. Hasoon, I. Collins, , N. D. Perkins

The paper identifies a c-Rel and USP1 dependent pathway that regulates CHK1 inhibitor resistance in lymphoma cells.

bioRxiv · May 26, 2021Cancer Biology

Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN

J. E. Hunter, J. A. Butterworth, H. Sellier, S. Luli, A. Floudas, A. J. Moore, H. D. Thomas, K. J. Campbell, N. S. Kenneth, R. T. Chiremba, D. Tiniakos, A. M. Knight, B. E. Gewurz, F. Oakley, M. D. Garrett, , N. D. Perkins

This study shows that CLSPN, regulated by NF-κB, influences checkpoint kinase signalling and tumorigenesis, with implications for cancer treatment resistance and biomarker potential.

bioRxiv · Jun 28, 2018 · PreprintCancer Biology