Human intestinal organoid-derived PDGFRα+ mesenchymal stroma empowers LGR4+ epithelial stem cells
C. JunLong, S. Horiuchi, S. Kuramochi, T. Kawasaki, H. Kawasumi, S. Akiyama, T. Arai, K. Morinaga, T. Kimura, T. Kiyono, H. Akutsu, S. Ishida, A. UMEZAWA
This study shows that organoid-derived mesenchymal stromal cells support the proliferation and functionality of hPSC-derived small intestinal epithelial stem cells in adherent culture.
bioRxiv · Aug 16, 2023 · PreprintCell Biology