S. Akiyama

This study shows that organoid-derived mesenchymal stromal cells support the proliferation and functionality of hPSC-derived small intestinal epithelial stem cells in adherent culture.

This study isolates and expands hepatic progenitor cells from human ESCs by selecting for drug-metabolizing activity, enabling a stable supply of functional liver cells for therapy and drug testing.

The paper shows that linear contraction of stress fibers drives cell body rotation in migrating keratocytes through simple soft-body mechanics.

This study shows that overexpressing adenylate kinase 1 in medaka fish increases locomotor activity, which is temperature-dependent.

The paper hypothesizes that colony-forming units in liver (CFU-L) can quantify the engraftment and functionality of hepatocyte-like cells derived from pluripotent stem cells.

This study investigates how the dual ATPase activities in KaiC coordinate to regulate the cyanobacterial circadian clock through structural and biochemical analysis.

The paper analyzes 85 million herbarium records to show colonial legacies in plant specimen distribution, revealing disparities between biodiversity hotspots and where specimens are housed.

The paper identifies the structural basis for allostery in the cyanobacterial circadian clock by analyzing KaiC protein states and shows how coupling between a phospho-switch and ATPase activity drives oscillation.

The paper investigates temperature compensation in the cyanobacterial circadian clock by analyzing KaiC dynamics using quasielastic neutron scattering and mutation studies.

This study develops a method to expand human hepatocytes in vitro using a cell-killing antibiotic, enabling long-term culture and stable supply for drug research.

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.