Author

H. Akutsu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. UMEZAWA· 7 shared M. Toyoda· 3 shared S. Akiyama· 3 shared S. Enosawa· 3 shared T. Kimura· 3 shared A. Nakazawa· 2 shared M. Kasahara· 2 shared M. Yamazaki-Inoue· 2 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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7 shared papersCell Biology

A. UMEZAWA

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Automated Xeno-Free Chondrogenic Differentiation from Human Embryonic Stem Cells: Enhancing Efficiency and Ensuring High-Quality Mass Production

J. Chen, O. Kataoka, K. Tsuchiya, Y. Oishi, A. Takao, Y.-C. Huang, H. Komura, S. Akiyama, R. Itou, M. Inui, S. Enosawa, H. Akutsu, M. Komura, Y. Fuchimoto, A. UMEZAWA

This study develops an automated xeno-free system for efficient chondrogenic differentiation of human embryonic stem cells, producing high-quality cartilage suitable for clinical applications.

bioRxiv · May 20, 2024Cell Biology

NMR analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria

T. Konuma, T. Takai, C. Tsuchiya, M. Nishida, M. Hashiba, Y. Yamada, H. Shirai, A. Nagadoi, E. Chikaishi, K.-i. Akagi, S. Akashi, T. Yamazaki, H. Akutsu, T. Ikegami

The paper determines the dimeric structure of VanX using NMR and identifies a monomeric form for inhibitor screening.

bioRxiv · Oct 13, 2023Biochemistry

Human intestinal organoid-derived PDGFRα+ mesenchymal stroma empowers LGR4+ epithelial stem cells

C. JunLong, S. Horiuchi, S. Kuramochi, T. Kawasaki, H. Kawasumi, S. Akiyama, T. Arai, K. Morinaga, T. Kimura, T. Kiyono, H. Akutsu, S. Ishida, A. UMEZAWA

This study shows that organoid-derived mesenchymal stromal cells support the proliferation and functionality of hPSC-derived small intestinal epithelial stem cells in adherent culture.

bioRxiv · Aug 16, 2023 · PreprintCell Biology

Hypothesis: Colony-forming activity of pluripotent stem cell-derived hepatocyte-like cells for stem cell assay

K. Ite, M. Toyoda, S. Akiyama, S. Enosawa, S. Yoshioka, T. Yukitake, M. Yamazaki-Inoue, K. Tatsumi, H. Akutsu, H. Nishina, T. Kimura, N. Ohtani, A. Nakazawa, A. Fukuda, M. Kasahara, A. UMEZAWA

The paper hypothesizes that colony-forming units in liver (CFU-L) can quantify the engraftment and functionality of hepatocyte-like cells derived from pluripotent stem cells.

bioRxiv · Nov 30, 2021 · PreprintCell Biology

Characterization of human embryonic stem cells in animal component-free medium

M. Machida, R. Abutani, H. Miyajima, T. Sasaki, Y. Abe, H. Akutsu, A. Umezawa

This study shows that SEES2 ESCs can be stably cultured in an animal component-free medium for 60 days without losing their karyotype or differentiation potential.

bioRxiv · Dec 14, 2020 · PreprintCell Biology

Immortalization of human zone I hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing

M. Nishiwaki, M. Toyoda, Y. Oishi, S. Ishida, S.-i. Horiuchi, H. Makino, T. Kimura, S.-i. Ohno, T. Ohkura, S. Enosawa, H. Akutsu, A. Nakazawa, M. Kasahara, T. Kiyono, A. Umezawa

The paper describes the creation of an immortalized hepatocyte cell line, HepaMN, from biliary atresia tissue and demonstrates its utility for cytochrome P450 induction testing.

bioRxiv · Aug 8, 2019 · PreprintCell Biology

Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors

K. Nishino, Y. Arai, K. Takasawa, M. Toyoda, M. Yamazaki-Inoue, T. Sugawara, H. Akutsu, K. Nishimura, M. Ohtaka, M. Nakanishi, A. Umezawa

The paper compares epigenetic differences in human iPSCs generated by three different vectors and finds Sendai virus generates the fewest aberrant methylation sites.

bioRxiv · Jun 25, 2018Cell Biology

Fetal therapy model of myelomeningocele with three-dimensional skin using amniotic fluid cell-derived induced pluripotent stem cells

K. Kajiwara, T. Tanemoto, S. Wada, J. Karibe, N. Ihara, Y. Ikemoto, T. Kawasaki, Y. Ohishi, O. Samura, K. Okamura, S. Takada, H. Akutsu, H. Sago, A. Okamoto, A. UMEZAWA

This study uses iPSC-derived artificial skin to treat a rat model of myelomeningocele during pregnancy, showing potential for antenatal therapy.

bioRxiv · Dec 19, 2016Cell Biology