C. K. Vanderpool

Transcriptional and post-transcriptional mechanisms modulate cyclopropane fatty acid synthase through small RNAs in Escherichia coli

This study identifies transcriptional and post-transcriptional regulators of RydC, an sRNA that modulates cyclopropane fatty acid synthase in E. coli, revealing a network linking membrane stress responses to environmental signals.

Small RNAs positively and negatively control transcription elongation through modulation of Rho utilization site accessibility

The paper shows that small RNAs in E. coli regulate gene expression by modulating Rho-dependent transcription termination in the cfa mRNA 5' UTR.

Mechanisms of regulation of cryptic prophage-encoded gene products in Escherichia coli

This study identifies layered regulatory mechanisms controlling the expression of a cryptic prophage-encoded operon in E. coli, including transcriptional repression, sRNA processing, and stress-dependent induction.

Small RNAs activate Salmonella pathogenicity island 1 by modulating mRNA stability through the hilD mRNA 3' UTR

This paper identifies small RNAs that regulate Salmonella virulence gene expression by modulating hilD mRNA stability through its 3' UTR.

A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron

This study identifies a novel family of RNA-binding proteins in Bacteroides thetaiotaomicron that regulate polysaccharide metabolism by controlling gene expression in response to dietary sugars.

The sRNA MicC downregulates hilD translation to control the SPI1 T3SS in Salmonella enterica serovar Typhimurium

This paper shows that the sRNA MicC inhibits hilD translation, thereby regulating SPI1 T3SS expression in Salmonella enterica serovar Typhimurium.

Kinetic model of small RNA-mediated regulation suggests that a small RNA can regulate co-transcriptionally

The paper develops a kinetic model to study sRNA-mediated gene regulation, revealing co-transcriptional regulation and identifying binding as a rate-limiting step.

Stochastic Analysis Demonstrates the Dual Role of Hfq in Chaperoning E. coli Sugar Shock Response

The paper uses single-cell microscopy and stochastic modeling to show Hfq stabilizes SgrS and aids its interaction with target mRNA during glucose-phosphate stress in E. coli.

Thiamine pyrophosphate riboswitches in Bacteroides species regulate transcription or translation of thiamine transport and biosynthesis genes

The paper investigates thiamine regulation in Bacteroides species, finding species-specific transcriptional and translational control mechanisms mediated by TPP riboswitches.

Cryptic prophage-encoded small protein DicB protects Escherichia coli from phage infection by inhibiting inner membrane receptor proteins

This study identifies DicB, a prophage-encoded protein in E. coli, which protects against phage infection by inhibiting phage receptors and sugar transport proteins.

Bacterial Cyclopropane Fatty Acid Synthase mRNA is targeted by activating and repressing small RNAs

The paper identifies three sRNAs that regulate cfa mRNA post-transcriptionally, with two activating and one repressing cfa expression in response to acid stress.

sRNA-target Prediction Organizing Tool (SPOT) integrates computational and experimental data to facilitate functional characterization of bacterial small RNAs

The paper introduces SPOT, a computational tool that integrates computational and experimental data to predict and validate bacterial sRNA targets, improving sensitivity over individual methods.

Determinants of target prioritization and regulatory hierarchy for the bacterial small RNA SgrS

This study investigates how the bacterial sRNA SgrS prioritizes and regulates its target mRNAs, revealing that regulatory hierarchy depends on binding site number, position, and cofactors like Hfq.

Translational regulation by bacterial small RNAs via an unusual Hfq-dependent mechanism

The paper identifies a non-canonical Hfq-dependent mechanism of translational repression by sRNAs, where Hfq directly represses translation rather than the sRNA itself.