Coenzyme A governs proinflammatory macrophage metabolism
G. A. Timblin, K. M. Tharp, J. t. Hoeve, D. S. Kantner, I. Baydemir, E. A. Noel, C. Khantwal, P. K. Singh, J. N. Farahzad, J. Dominguez-Andres, R. E. Vance, N. W. Snyder, V. M. Weaver
This study shows that exogenous CoA enhances TLR-driven proinflammatory and antimicrobial responses in macrophages by promoting oxidative metabolism and histone acetylation.
bioRxiv · Aug 30, 2022 · PreprintImmunology