Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness
A. P. Gomes, D. Ilter, V. Low, J. Endress, J. Fernandez-Garcia, A. Rosenzweig, T. Schild, D. Broekaert, A. Ahmed, M. Planque, I. Elia, J. Han, C. Kinzig, E. Mullarky, A. Mutvei, , J. Blenis
The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.
bioRxiv · Jun 4, 2020 · PreprintCancer Biology