J. Han

The Genome In A Bottle HG002 assembly-based variant benchmark set enables comprehensive benchmarking of small and structural variants.

The paper introduces a comprehensive variant benchmark set derived from a high-quality diploid assembly, improving small and structural variant detection across complex genomic regions.

An extinct clade sister to Eumetazoa: On the phylogeny of the Cambrian chancelloriids

This study describes new fossils of chancelloriids, revealing their unique body plan and suggesting they are a basal clade sister to eumetazoans.

Structural Mapping of Polyclonal IgG Responses to HA After Influenza Virus Vaccination or Infection

The paper uses nsEMPEM to analyze polyclonal IgG responses to HA in vaccinated and infected individuals, showing differences in epitope targeting between H1 and H3 subtypes.

Basal Cambrian soft-bodied segmented bilaterians preserved as microbial pseudomorphs

This study identifies microbial pseudomorphs as the earliest three-dimensional body fossils of segmented bilaterians from the basal Cambrian, revealing a diversified bilaterian world.

Genetic and cellular basis of impaired phagocytosis and photoreceptor degeneration in CLN3 disease.

This study investigates how CLN3 mutations impair phagocytosis and cause photoreceptor degeneration in CLN3 disease using patient-derived cells and a miniswine model.

Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

A receptor kinase complex refines cambium activity in Arabidopsis

This study identifies PXY-ER complexes as essential for cambium activity in Arabidopsis, showing that PXY signaling depends on ER signaling and explains ER function in the cambium.

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

This study uses single nucleus RNA-Seq to show increased adipogenesis and IGF-1R pathway alterations in TED orbital fat, suggesting linsitinib as a potential therapeutic.

Delta-5 elongase knockout reduces DHA and TAG synthesis coupled with an increase of heat sensitivity in a marine diatom

This study shows that knocking out delta-5 elongase in a marine diatom reduces DHA and TAG synthesis and increases heat sensitivity.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

A tale of two fusion proteins: understanding the metastability of human respiratory syncytial virus and metapneumovirus and implications for rational design of uncleaved prefusion-closed trimers

The study analyzes metastability in fusion proteins of RSV and hMPV to design stable uncleaved prefusion-closed trimers for vaccine development.

Salidroside and its in vivo metabolite tyrosol could act directly on dopamine D2 receptors: a study using RNAseq combined with Connectivity Map analysis

This study identifies dopamine D2 receptor as a potential target for salidroside and its metabolite tyrosol using RNAseq and Connectivity Map analysis, supported by molecular docking and binding assays.

Bypassing PELO-mediated ATPase activation of NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases

The paper identifies that pathogenic NLR mutations cause PELO-independent ATPase activation, leading to inflammatory responses and disease, and suggests this as a diagnostic marker.

Early evolution of the ecdysozoan body plan

The paper describes a new Cambrian ecdysozoan species, Beretella spinosa, and suggests that ancestral ecdysozoans may have been non-vermiform.

Serine hydroxymethyl transferase is a binding target of caprylic acid: Uncovering a novel molecular target for a herbicide and for producing caprylic acid-tolerant crops

This study identifies serine hydroxymethyl transferase (SHMT) as a binding target of caprylic acid, showing its role in herbicidal activity and potential for developing tolerant crops.

Not dasycladalean alga, but an Odyssey of the earliest Phanerozoic animal reef-builders

The paper reclassifies Protomelission? sp. as archaeocyath-like sponges, challenging previous interpretations and providing insights into early animal reef-building.

Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants

This study uses deep learning to identify antibodies resistant to SARS-CoV-2 Omicron variants by predicting their binding and escape from mutations.

Bio-inspired mineralization collagen induce fibrocartilage regeneration after tendon-bone injury by activating Gli1+Dkk3+ progenitor cells

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

Stereotypic persistent B cell receptor clonotypes in Alzheimer's Disease

The paper identifies stereotypic BCR clonotypes in Alzheimer's Disease patients that persist over time and are not found in healthy controls, suggesting potential diagnostic signatures.

Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines

The paper introduces a triple tandem trimer (TTT) design for HIV-1 Env and influenza HA immunogens, showing improved trimer-specific immune responses in viral vectored vaccines.

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

This study examines how prior H2 influenza exposure influences polyclonal antibody responses to H2N2 vaccination, showing differences in epitope targeting between H2-exposed and H2-naive individuals.

Resident memory T cell precursors in tumor draining lymph nodes require type-1 IFN for optimal differentiation

Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

Identification of cambium stem cell factors and their positioning mechanism

The paper identifies TDIF ligand-activated PXY receptors and CAIL transcription factors as key to defining cambium stem cell identity in Arabidopsis roots and explains their positioning mechanism.

Metabolomic approaches highlight two mechanisms of accelerated grain filling in Mediterranean oat (Avena sativa L.) cultivars during drought.

This study compares drought responses in two oat cultivars, identifying metabolomic mechanisms underlying accelerated grain filling in a tolerant cultivar.

Altitude-dependent agro-ecologies impact the microbiome diversity of scavenging indigenous chicken in Ethiopia

The study examines how altitude-dependent agro-ecologies affect the microbiome diversity of scavenging indigenous chickens in Ethiopia, identifying environmental factors influencing microbial composition.

Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation

This paper develops APB-R3, a long-acting IL-18 blocker, showing efficacy in reducing inflammation in macrophage activation syndrome and atopic dermatitis models.

Synergistic effects of multiple pesticides on the flight ability of honey bees (Apis cerana F.)

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

Scalable Mesenchymal Stem Cells Enrichment from Bone Marrow Aspirate using Deterministic Lateral Displacement (DLD) Microfluidics Sorting

This paper develops a microfluidic method to isolate mesenchymal stem cells from bone marrow aspirate more efficiently than centrifugation.

Single-cell mutation rate of turnip crinkle virus (-)-strand replication intermediates

This study estimates the mutation rate of turnip crinkle virus (-)-strand replication intermediates in single cells and supports the BIAS replication model.