ORF3c is expressed in SARS-CoV-2 infected cells and suppresses immune activation by inhibiting innate sensing
M. Mueller, A. Herrmann, S. Fujita, J. E. Kolberg, C. Kruth, A. Strange, M. Schneider, J. Ito, A. Ensser, The Genotype to Phenotype Japan (G2P-Japan) Consortium, K. Sato, D. Sauter
This study identifies ORF3c as an immune evasion factor of SARS-CoV-2 that suppresses innate sensing by inhibiting RIG-I and MDA5 signaling.
bioRxiv · Feb 27, 2023Microbiology