M. Mueller

Dbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies

This paper develops and characterizes RNB-61, a potent and selective CB2R agonist with favorable pharmacokinetics, showing nephroprotective effects in kidney injury models.

Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation

This study identifies PUN motifs in yeast Loc1p that cooperate to catalyze RNA folding and drive phase separation, suggesting a role in RNA and DNA-related processes across species.

High sensitivity cameras can lower spatial resolution in high-resolution optical microscopy

This study shows that highly sensitive cameras can reduce spatial resolution in high-resolution optical microscopy due to differences in their modulation transfer function.

Enhanced cardiac mitochondrial biogenesis by nitro-oleic acid remedies diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction

NO2-OA treatment improves diastolic dysfunction in HFpEF mice by enhancing mitochondrial biogenesis and oxidative phosphorylation.

Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2

This study identifies small molecule inhibitors that bind to apo-TDO2 and inhibits its activity at low nanomolar concentrations, along with their co-crystal structures.

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity

This study shows sodium chloride enhances CD8+ T-cell metabolic fitness and cytotoxicity, improving tumor cell killing in vitro and in vivo.

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

Characterization, Comparison, and Optimization of Lattice Light Sheets

This paper compares and optimizes lattice light sheets to improve resolution and reduce photobleaching in light sheet microscopy.

ORF3c is expressed in SARS-CoV-2 infected cells and suppresses immune activation by inhibiting innate sensing

This study identifies ORF3c as an immune evasion factor of SARS-CoV-2 that suppresses innate sensing by inhibiting RIG-I and MDA5 signaling.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

Targeting de novo loss of function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes Project

The paper introduces DeNovoLOEUF, a method to identify diagnostic variants in genome sequencing data, achieving 96% positive predictive value and uncovering 39 missed diagnoses in the 100,000 Genomes Project.

An intermediate effect size variant in UMOD confers risk for chronic kidney disease

The paper identifies an intermediate-effect variant in UMOD associated with chronic kidney disease risk and shows it has reduced disease severity compared to canonical ADTKD mutations.

Persistence of Plasmodium cynomolgi hypnozoites in cynomolgus monkey iPS-derived hepatocytes

This study develops an in vitro model using cynomolgus monkey iPS-derived hepatocytes to study Plasmodium cynomolgi hypnozoite formation and liver stage dormancy, aiding drug discovery.

AGO1 regulates pericentromeric regions in mouse embryonic stem cells

This study shows that AGO1 depletion in mESCs causes redistribution of H3K9me3 and HP1 away from pericentromeres and upregulates major satellite transcripts.

Synthesis and Structure Elucidation of the Human tRNA Nucleoside Mannosyl-Queuosine

The paper reports the correct structure of mannosyl-queuosine (manQ) through total synthesis and LC-MS-co-injection, revealing a novel -allyl connectivity and differing glycosylase preferences.

A synthetic protein as efficient multitarget regulator against complement over-activation

The paper designs a synthetic protein, MFHR13, that enhances complement regulation and shows improved therapeutic activity compared to existing treatments.

Structured illumination microscopy with noise-controlled image reconstructions

This paper introduces noise-controlled reconstruction methods for structured illumination microscopy to reduce artefacts and improve image quality.

Absent expansion of pericentral hepatocytes and altered physiology in Axin2CreERT2 mice

This study re-evaluates lineage tracing in Axin2CreERT2 mice and reports absence of pericentral hepatocyte expansion and altered Wnt pathway physiology.

Demographics and Employment of Max-Planck Society's Postdocs

The paper surveys Max Planck Society postdocs to assess demographics, employment conditions, and disparities in access to employment types, wages, and social benefits.

Human Papillomavirus Type 16 L1/L2 VLP Experimental Internalization by Human Peripheral Blood Leukocytes

This study shows HPV16 L1/L2 VLPs can enter human peripheral blood leukocytes via CD71 transferrin receptors, with varying uptake rates among cell types.

A Modular Approach to Active Focus Stabilization for Fluorescence Microscopy

This paper presents a modular, cost-effective system for detecting and correcting z-drift in fluorescence microscopy, demonstrating its effectiveness through temperature perturbation and simulated stage movement tests.

Thin Film Metallization Stacks Serve as Reliable Conductors on Ceramic-based Substrates for Active Implants

This paper develops a thin film metallization process for ceramic-based active implants that improves adhesion and reduces soldering time compared to traditional screen-printing methods.

Human and mouse essentiality screens as a resource for disease gene discovery

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

Ibotenic acid biosynthesis in the fly agaric is initiated by glutamate hydroxylation

The paper identifies and characterizes a glutamate hydroxylase in Amanita muscaria, supporting the hypothesis that ibotenic acid biosynthesis begins with 3-hydroxyglutamate.

On the Reliability of Chronically Implanted Thin-Film Electrodes in Human Arm Nerves for Neuroprosthetic Applications

This study evaluates the long-term reliability of thin-film electrodes implanted in human arm nerves, showing no corrosion or degradation after six months.

De novo Classification of Mouse B Cell Types using Surfaceome Proteotype Maps

The paper develops autoCSC, a miniaturized surfaceome mapping technology, to classify mouse B cell types and identify developmental subpopulations.

Quantitative comparison of camera technologies for cost-effective Super-resolution Optical Fluctuation Imaging (SOFI)

This study compares camera technologies for cost-effective Super-resolution Optical Fluctuation Imaging (SOFI), showing that industrial-grade detectors can achieve SOFI on standard and home-built microscopes.

Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless

This study determines the NMR structure of MLE's dsRBD1 and dsRBD2 and shows they bind dsRNA independently, but dsRBD1 mutants do not affect roX2 binding or MLE localization.