ImmunologybioRxiv
Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis
C. L. Grandjean, Z. Garcia, F. Lemaitre…·P. Bousso
This study uses intravital imaging to show that antibody-dependent phagocytosis by bone marrow macrophages is the main mechanism of anti-CD20 therapy, but its efficiency is limited by time and spatial constraints.