Author

C. L. McCafferty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

D. W. Taylor· 4 shared E. M. Marcotte· 4 shared O. Papoulas· 3 shared J. B. Wallingford· 2 shared A. Ghanaeian· 1 shared B. Nami· 1 shared C. Lee· 1 shared C. Nichols· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

D. W. Taylor

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Author profile →

5 papers

Recent·Most cited

An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexes

C. L. McCafferty, O. Papoulas, C. Lee, K. H. L. Bui, D. W. Taylor, E. M. Marcotte, J. B. Wallingford

The paper defines an amino acid-resolution interactome of motile cilia using XL/MS in Tetrahymena thermophila, revealing structural and functional insights into ciliary machines and ciliopathy proteins.

bioRxiv · Jul 9, 2023 · PreprintCell Biology

Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism

A. Ghanaeian, S. Majhi, C. L. McCafferty, B. Nami, C. S. Black, S. K. Yang, T. Legal, O. Papoulas, M. Janowska, M. Valente-Paterno, E. M. Marcotte, D. Wloga, K. H. Bui

The paper uses cryo-EM and integrative modeling to localize DRC subunits in the N-DRC of Tetrahymena thermophila and identifies interacting coiled-coil proteins.

bioRxiv · May 31, 2023Cell Biology

Integrative modeling reveals the molecular architecture of the Intraflagellar Transport A (IFT-A) complex

C. L. McCafferty, O. Papoulas, M. A. Jordan, G. Hoogerbrugge, C. Nichols, G. Pigino, D. W. Taylor, J. B. Wallingford, E. M. Marcotte

The paper models the structure of the IFT-A complex using experimental and computational methods, revealing insights into ciliopathy-associated mutations.

bioRxiv · Jul 5, 2022Biochemistry

Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex

E. A. Schwartz, J. P. Bravo, L. A. Macias, C. L. McCafferty, T. L. Dangerfield, J. N. Walker, J. S. Brodbelt, P. C. Fineran, R. D. Fagerlund, D. W. Taylor

The paper determines the structure of a type III-D CRISPR-Cas effector complex and characterizes its RNA cleavage mechanism, revealing how multi-subunit fusion proteins assemble into an active RNA endonuclease.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry

Improving integrative 3D modeling into low- to medium- resolution EM structures with evolutionary couplings

C. L. McCafferty, D. W. Taylor, E. M. Marcotte

The paper improves integrative 3D modeling of low- to medium-resolution EM structures using evolutionary couplings to better fit atomic models into EM maps.

bioRxiv · Jan 14, 2021 · PreprintBiochemistry