Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex
E. A. Schwartz, J. P. Bravo, L. A. Macias…·D. W. Taylor
The paper determines the structure of a type III-D CRISPR-Cas effector complex and characterizes its RNA cleavage mechanism, revealing how multi-subunit fusion proteins assemble into an active RNA endonuclease.