Author

C. L. Walker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:genome assembly· 1

Frequent Co-Authors

R. Dere· 4 shared C. Coarfa· 2 shared D. N. Tripathi· 2 shared F. M. Mason· 2 shared K. J. Verhey· 2 shared M. Karki· 2 shared R. K. Jangid· 2 shared R. N. H. Seervai· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCell Biology

R. Dere

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lysine Demethylase 4A is a Centrosome Associated Protein Required for Centrosome Integrity and Genomic Stability

P. Chowdhury, X. Wang, J. F. Love, S. Vargas-Hernandez, Y. Nakatani, S. L. Grimm, D. Mezquita, F. M. Mason, E. D. Martinez, C. Coarfa, C. L. Walker, A.-K. Gustavsson, R. Dere

This study identifies KDM4A as a centrosome-associated protein whose demethylase activity maintains centrosome integrity and genomic stability.

bioRxiv · Feb 20, 2024Cell Biology

SETD2 safeguards the genome against isochromosome formation

F. Mason, E. S. Kounlavong, A. T. Tebeje, R. Dahiya, T. Guess, L. Vlach, S. R. Norris, C. A. Lovejoy, R. Dere, R. Ohi, P. Ly, C. L. Walker, W. K. Rathmell

This study shows that SETD2 loss leads to chromosome segregation errors and DNA bridging via isochromosome formation, contributing to genomic instability in cancer.

bioRxiv · Oct 25, 2022 · PreprintCancer Biology

A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules

M. Karki, R. K. Jangid, R. N. H. Seervai, J.-P. Bertocchio, T. Hotta, P. Msaouel, S. Y. Jung, S. L. Grimm, C. Coarfa, B. E. Weissman, R. Ohi, K. J. Verhey, C. H. Hodges, R. Dere, I.-Y. Park, , D. N. Tripathi

This study identifies PBRM1 as the first cytoskeletal reader for SETD2-mediated -tubulin methylation, revealing a new role for PBRM1 in mitotic spindle organization and genomic stability.

Science Advances · Apr 2, 2021Peer-reviewedCell Biology

SETD2 is an actin lysine methyltransferase

R. N. H. Seervai, R. K. Jangid, M. Karki, D. N. Tripathi, S. Y. Jung, S. E. Kearns, K. J. Verhey, M. A. Cianfrocco, B. A. Millis, M. J. Tyska, F. M. Mason, W. K. Rathmell, I. Y. Park, R. Dere, C. L. Walker

This study identifies SETD2 as an actin lysine methyltransferase that regulates actin polymerization and cell migration through methylation of the actin cytoskeleton.

bioRxiv · Apr 13, 2020 · PreprintCell Biology