Author

L. Vlach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Florian· 1 shared A. T. Tebeje· 1 shared B. C. Grieb· 1 shared B. N. Smith· 1 shared C. A. Lovejoy· 1 shared C. Jones· 1 shared C. L. Walker· 1 shared E. M. Reynolds· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. C. Florian

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Author profile →

2 papers

Recent·Most cited

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

G. C. Howard, J. Wang, K. L. Rose, C. Jones, P. Patel, T. Tsui, A. C. Florian, L. Vlach, S. L. Lorey, B. C. Grieb, B. N. Smith, M. J. Slota, E. M. Reynolds, S. Goswami, M. R. Savona, , W. P. Tansey

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

bioRxiv · Jul 26, 2023Cancer Biology

SETD2 safeguards the genome against isochromosome formation

F. Mason, E. S. Kounlavong, A. T. Tebeje, R. Dahiya, T. Guess, L. Vlach, S. R. Norris, C. A. Lovejoy, R. Dere, R. Ohi, P. Ly, C. L. Walker, W. K. Rathmell

This study shows that SETD2 loss leads to chromosome segregation errors and DNA bridging via isochromosome formation, contributing to genomic instability in cancer.

bioRxiv · Oct 25, 2022 · PreprintCancer Biology