C. Coarfa

Let-7 restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosis

This study identifies let-7 as a regulator of AT2 cell differentiation and fibrosis prevention by controlling oncogenic networks and epigenetic changes.

Lysine Demethylase 4A is a Centrosome Associated Protein Required for Centrosome Integrity and Genomic Stability

This study identifies KDM4A as a centrosome-associated protein whose demethylase activity maintains centrosome integrity and genomic stability.

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct

This study compares infant and adult human intestinal enteroids, finding significant transcriptomic, morphological, and functional differences that highlight their distinct characteristics.

Adipose triglyceride lipase is regulated by CAMKK2-AMPK signaling and drives advanced prostate cancer

This study identifies ATGL as a CAMKK2-AMPK target that promotes CRPC progression by enhancing lipase activity and metabolic plasticity, suggesting it as a therapeutic target.

D-mannose ameliorates age-associated cellular senescence in the bladder urothelium and NLRP3/Gasdermin/IL-1β -driven pyroptotic epithelial cell shedding

This study shows that D-mannose reduces age-related bladder urothelial senescence and pyroptotic cell shedding in mice by improving autophagy and reversing SASP.

Telomere dysfunction impairs intestinal differentiation andpredisposes to diet-induced colitis

This study shows that telomere shortening impairs intestinal differentiation, leading to barrier defects and diet-induced colitis through microbiome modulation and nutrient flux.

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma with direct translational applications

This paper develops a genetically engineered mouse model of rhabdomyosarcoma with molecular features similar to human RMS, providing pre-clinical tools for therapy evaluation.

Effect of Substrate Stiffness on Human Intestinal Enteroids Infectivity by Enteroaggregative Escherichia coli

This study shows that substrate stiffness affects the adherence of EAEC bacteria to human intestinal enteroids, with softer hydrogels promoting larger bacterial aggregates.

Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection.

The paper compares RSV infection in HEp-2 and A549 cells using four strains, finding subgroup-dependent gene expression differences and A549's greater antiviral response.

A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules

This study identifies PBRM1 as the first cytoskeletal reader for SETD2-mediated -tubulin methylation, revealing a new role for PBRM1 in mitotic spindle organization and genomic stability.

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis

The paper identifies a novel, targetable macrophage population in idiopathic pulmonary fibrosis using single-cell RNA-seq, CyTOF, and flow cytometry.

Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors

This study shows that activating CAR with HBx in mice leads to liver tumors with strong β-catenin activation, mirroring human HBV-related HCC.

STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

The paper investigates how STAT1 activity in adipocytes affects insulin sensitivity in obesity, finding that STAT1 deletion improves mitochondrial function but does not resolve insulin resistance.

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.

Bacteria-to-human protein networks reveal origins of endogenous DNA damage

The paper identifies DNA-damaging proteins in E. coli and their human homologs, showing they promote endogenous DNA damage and are overrepresented in cancer drivers.

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes

This study shows helminth infections cause long-term DNA methylation and immune changes that impair TB-specific immune responses.

Beyond Autoantibodies: Biological Roles Of Human Autoreactive B Cells In Rheumatoid Arthritis Revealed By Whole Transcriptome Profiling

This study identifies novel roles of autoreactive B cells in RA through transcriptome profiling, revealing potential therapeutic targets and mechanisms.