P. Ly

Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer

This study shows that dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-deficient prostate cancer cells, with Compound B effectively achieving this in vitro and in vivo.

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors

This study shows that non-homologous end joining (NHEJ) is the main pathway causing complex genomic rearrangements during chromothripsis from mitotic errors.

Mitotic clustering of pulverized chromosomes from micronuclei

This study shows that acentric chromosome fragments from micronuclei cluster during mitosis, leading to biased inheritance and balanced chromothripsis in cancer.

SETD2 safeguards the genome against isochromosome formation

This study shows that SETD2 loss leads to chromosome segregation errors and DNA bridging via isochromosome formation, contributing to genomic instability in cancer.

Epigenetic dysregulation from chromosomal transit in micronuclei

This study shows that chromosomal transit through micronuclei causes epigenetic dysregulation in cancer cells, leading to long-term chromatin accessibility abnormalities.

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

Restoration of deficient DNA Repair Genes Mitigates Genome Instability and Increases Productivity of Chinese Hamster Ovary Cells

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.