Dynamic 3D chromosomal landscapes in acute leukemia
A. Kloetgen, P. Thandapani, P. Ntziachristos, Y. Ghebrechristos, S. Nomikou, C. Lazaris, X. Chen, H. Hu, S. Bakogianni, J. Wang, Y. Fu, F. Boccalatte, H. Zhong, E. Paietta, T. Trimarchi, , A. Tsirigos
The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.
bioRxiv · Aug 4, 2019Cancer Biology