Y. Fu

Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface

This study uses single-molecule microscopy to investigate influenza A virus-induced nanoscale cellular changes at the virus-cell interface, revealing receptor dynamics and actin cortex responses.

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

The paper identifies 44 compounds with >50% inhibitory effects against Toxoplasma gondii bradyzoites using a high-throughput screen and characterizes one compound's activity.

Structural basis for transcription activation through cooperative recruitment of MntR

This study determines the structural basis of MntR-mediated gene activation through cooperative DNA binding using cryo-EM and complementary assays.

Drought resistance and improved yield result from modified malate metabolism in guard and vascular companion cells

This study shows that modifying malate metabolism in specific plant cells improves drought resistance without reducing yield.

Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments

The paper compares fitness of microbial metabolic strategies in fluctuating environments, finding sequential utilizers gain an advantage in diverse communities.

Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1alpha-mediated glycolysis

This study identifies that impaired NK cell migration in HIV-infected individuals is due to TIGIT inhibiting HIF-1-mediated glycolysis through PI3K/AKT/mTORC1 or ERK pathways.

Peripheral B Lymphocyte Serves as A Reservoir for The Persistently Covert Infection of Mandarinfish Siniperca chuatsi Ranavirus

This study identifies peripheral B lymphocytes as a viral reservoir for persistent and covert Mandarinfish Ranavirus (MRV) infection, revealing a unique reactivation mechanism distinct from other ranaviruses.

Mutability and hypermutation antagonize immunoglobulin codon optimality

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

A rapid and efficient in vivo inoculation method for introducing tree stem canker pathogens onto leaves: Suitable for large-scale assessment of resistance in poplar breeding progeny

This paper introduces an in vivo leaf inoculation method for assessing poplar resistance to V. sordida, showing it is more efficient and suitable for large-scale screening than traditional stem segment inoculation.

Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of Toxoplasma gondii.

This paper identifies a Toxoplasma gondii isolate that constitutively expresses bradyzoite regulators and readily differentiates into mature bradyzoites under stress, providing a new in vitro model for studying chronic infection.

Morroniside promotes skin wound re-epithelialization by facilitating epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin expression

This study shows that morroniside promotes skin wound healing by enhancing epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin and downstream targets.

ATM-Mediated Translocation of RanBPM Regulates DNA Damage Response by Stabilizing p21 in Non-Small Cell Lung Cancer Cells

The paper identifies a novel mechanism where RanBPM stabilizes p21 via deubiquitination, regulating DNA damage response in NSCLC cells.

Predicting protein curvature sensing across membrane compositions with a bilayer continuum model

The paper develops a bilayer continuum model to predict how lipid composition affects protein curvature sensing in membranes.

Genotype, antimicrobial resistance and virulence profiles of livestock-derived enterotoxigenic Escherichia coli (ETEC) in the United States, 1970-2023

This study compares genotype, antimicrobial resistance, and virulence profiles of bovine and swine ETEC in the US from 1970-2023, finding distinct genetic and resistance patterns between the two hosts.

High-speed Auto-Polarization Synchronization Modulation Three-dimensional Structured Illumination Microscopy

This paper introduces a high-speed 3DSIM system using DMD and electro-optic modulators, achieving improved resolution and imaging speed for various biological specimens.

Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments

This study introduces METRIC, a deep-learning method that uses gut microbiome data to correct random errors in self-reported dietary assessments, showing effectiveness in simulated and real-world datasets.

FrameDiPT: SE(3) Diffusion Model for Protein Structure Inpainting

FrameDiPT is a diffusion model for protein structure inpainting that recovers masked sections using sequence and structural context, achieving comparable accuracy to existing models with limited data.

Connecting Chromatin Structures to Gene Regulation Using Dynamic Polymer Simulations

The paper uses polymer simulations to model chromatin dynamics and shows that productive interactions depend on contact frequency, capture radius, and duration, not just average contact matrices.

Live soil ameliorated the negative effects of biodegradable but not non-biodegradable microplastics on the growth of plant communities

The paper tests how biodegradable and non-biodegradable microplastics affect plant communities in live vs. sterilized soil, finding live soil mitigates biodegradable plastic effects but both types suppress diversity more in live soil.

Cep290 is cooperatively maintained at basal body by Cep131-Cep162 and Cby-Fam92 modules

This study identifies two modules, Cep131-Cep162 and Cby-Fam92, that cooperatively maintain Cep290 at the basal body and initiate ciliogenesis.

Duhuo Jisheng Decoction Regulates Intracellular Zinc Homeostasis by Enhancing Autophagy via PTEN/Akt/mTOR to Improve Knee Cartilage Degeneration

This study investigates how Duhuo Jisheng Decoction protects cartilage by enhancing autophagy through the PTEN/Akt/mTOR pathway and regulating zinc homeostasis.

GAGA zinc finger transcription factor searches chromatin by 1D-3D facilitated diffusion

This study tracks GAF's chromatin search mechanism using smFRET and imaging, showing 1D-3D diffusion enables efficient target finding despite nucleosome barriers.

Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth

The paper identifies indole metabolites from the microbiota that inhibit Cryptosporidium parvum growth by disrupting host mitochondrial function and parasite mitosome membrane potential.

Ferroptosis induced by phenolic compound-iron complex

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.

An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies

This paper characterizes the binding specificity and epitope of a broadly neutralizing anti-SARS-CoV-2 Spike RBD antibody using mAb-resistant virions and cryo-EM structural analysis.

Comparative Phylogenomics and Phylotranscriptomics Provide Insights into the Genetic Complexity of Nitrogen Fixing Root Nodule Symbiosis

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

Noise-robust, physical microscopic deconvolution algorithm enabled by multi-resolution analysis regularization

This paper introduces noise-robust deconvolution algorithms for fluorescence microscopy using multi-resolution analysis regularization, improving resolution and SNR across various imaging techniques.

PRL1 negatively regulates Rho GTPase-independent and -dependent signaling pathways maintaining actin microfilament dynamic for pavement cell morphogenesis

This study identifies PRL1 as a regulator of actin microfilament dynamics in Arabidopsis pavement cells through both Rho GTPase-dependent and -independent pathways.

Angiopoietin-like 4 promotes the proliferation and migration of epidermal stem cells and contributes to the re-epithelialization of cutaneous wounds

This study shows ANGPTL4 promotes epidermal stem cell proliferation and migration, enhancing wound re-epithelialization in mice.

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combine with droplet microfluidics

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.