Salicylate, Bile Acids and Extreme Acid Cause Fitness Tradeoffs for Multidrug Pumps in Escherichia coli K-12
S. H. Schaffner, A. V. Lee, M. T. Pham, B. B. Kassaye, H. Li, S. Tallada, C. Lis, M. Lang, Y. Liu, N. Ahmed, L. G. Galbraith, J. P. Moore, K. M. Bischof, J. L. Slonczewski
This study investigates how salicylate, bile acids, and extreme acid affect the fitness of multidrug efflux pumps in E. coli, revealing tradeoffs and conditions under which these pumps confer advantages or costs.
bioRxiv · Nov 21, 2020 · PreprintMicrobiology