Obesity promotes breast epithelium DNA damage in BRCA mutation carriers
P. Bhardwaj, N. M. Iyengar, H. Zahid, K. M. Carter, D. J. Byun, M.-H. Choi, Q. Sun, O. Savenkov, C. Louka, C. Liu, P. Piloco, M. Acosta, R. Bareja, O. Elemento, M. Foronda, , K. A. Brown
The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.
bioRxiv · Jul 29, 2022 · PreprintCancer Biology