Author

M. Foronda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

B. J. Diaz· 3 shared L. E. Dow· 3 shared S. Goswami· 3 shared A. Katti· 2 shared L. Dow· 2 shared M. P. Zafra· 2 shared O. Elemento· 2 shared A. M. Laughney· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

B. J. Diaz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

A. Katti, M. Foronda, J. Zimmermann, M. P. Zafra, S. Goswami, E. E. Gardner, B. J. Diaz, J. M. Simon, A. Wuest, W. Luan, M. T. C. Fernandez, A. P. Kadina, J. A. Walker, K. Holden, F. J. Sanchez-Rivera, , L. E. Dow

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

bioRxiv · Aug 3, 2022 · PreprintCancer Biology

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

P. Bhardwaj, N. M. Iyengar, H. Zahid, K. M. Carter, D. J. Byun, M.-H. Choi, Q. Sun, O. Savenkov, C. Louka, C. Liu, P. Piloco, M. Acosta, R. Bareja, O. Elemento, M. Foronda, , K. A. Brown

The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.

bioRxiv · Jul 29, 2022 · PreprintCancer Biology

GO: A functional reporter system to identify and enrich base editing activity

A. Katti, M. Foronda, J. Zimmerman, B. J. Diaz, M. P. Zafra, S. Goswami, L. E. Dow

The paper introduces a functional reporter system called GO to identify and enrich base editing activity in cells with high sensitivity and specificity.

bioRxiv · Dec 3, 2019Bioengineering

A machine learning approach predicts essential genes and pharmacological targets in cancer

C. Gilvary, N. Madhukar, K. Gayvert, M. Foronda, A. Perez, C. S. Leslie, L. Dow, G. Pandey, O. Elemento

This paper introduces ECLIPSE, a machine learning model that predicts essential genes and pharmacological targets in cancer by integrating genomic, cell line, and experimental features, showing better differentiation of approved cancer drugs from non-approved ones.

bioRxiv · Jul 4, 2019 · PreprintCancer Biology

Tankyrase inhibition sensitizes cells to CDK4 blockade

M. Foronda, Y. Tarumoto, E. M. Schatoff, B. I. Leach, B. J. Diaz, S. Goswami, M. Shusterman, C. R. Vakoc, L. Dow

This study identifies that combining TNKS inhibition with CDK4 loss drives G1 cell cycle arrest and senescence in epithelial cancers.

bioRxiv · Jun 21, 2019Cancer Biology