Q. Sun

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Complete enzymatic depolymerization of polyethylene terephthalate (PET) plastic using a Saccharomyces cerevisiae-based whole-cell biocatalyst

This paper develops a Saccharomyces cerevisiae-based whole-cell biocatalyst that completely depolymerizes PET plastic using a multi-enzyme cluster, achieving 4.9 mM TPA in seven days.

Beyond the Colony-Forming-Unit: Rapid Bacterial Evaluation in Osteomyelitis

This study demonstrates the discrepancy between colony-forming-unit and bacterial genome copy number in osteomyelitis and proposes an improved workflow for bacterial burden quantification in clinical specimens.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Peripheral B Lymphocyte Serves as A Reservoir for The Persistently Covert Infection of Mandarinfish Siniperca chuatsi Ranavirus

This study identifies peripheral B lymphocytes as a viral reservoir for persistent and covert Mandarinfish Ranavirus (MRV) infection, revealing a unique reactivation mechanism distinct from other ranaviruses.

High-efficiency PET Degradation with a Duo-enzyme System Immobilized on Magnetic Nanoparticles

This study develops a duo-enzyme system for PET degradation by immobilizing PETase and MHETase on magnetic nanoparticles, achieving higher product release and enzyme stability.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Differential Proteomic Analysis of AML Patients at Low and Intermediate Altitudes after Chemotherapy

This study identifies proteomic differences between AML patients at low and intermediate altitudes after chemotherapy, highlighting variations in metabolic and signaling pathways.

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.

The Zea mays PeptideAtlas; a new maize community resource

The paper develops the Maize PeptideAtlas resource to analyze maize proteomes using MS/MS data, identifying peptides and proteins across diverse genetic backgrounds and conditions.

Mutation of OsCDS5 confers broad-spectrum disease resistance in rice

This study shows that mutating OsCDS5 in rice enhances resistance to multiple diseases by increasing ROS production and defense gene expression.

Strong cascading impacts of micropollutants on planktonic food web in urban river

This study examines how micropollutants affect planktonic food webs in urban rivers, finding stronger impacts in more urbanized areas with algal-mediated cascading effects.

Elucidating the molecular determinants for binding modes of a third-generation HIV-1 integrase strand transfer inhibitor: Importance of side chain and solvent reorganization

This study identifies molecular determinants of binding modes for a third-generation HIV-1 integrase inhibitor, showing that side chain and solvent reorganization, along with conformational entropy, influence ligand binding preferences in closely related viral intasomes.

Floral scent emission of Epiphyllum oxypetalum: identification of a novel cytosol-localized geraniol biosynthesis pathway

This study identifies a novel cytosol-localized geraniol biosynthesis pathway in Epiphyllum oxypetalum using volatilomic, transcriptomic, and biochemical approaches.

Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments

This study introduces METRIC, a deep-learning method that uses gut microbiome data to correct random errors in self-reported dietary assessments, showing effectiveness in simulated and real-world datasets.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Rho of plant GTPase MxROP1 regulates Fe deficiency responses by targeting Zinc Ribbon 3 in apple rootstock

This study identifies MxROP1 as a regulator of Fe deficiency responses in apple rootstock by interacting with ZR3.1 and modulating its stability and interaction with MxbHLH39.

Detection and editing of the updated plastid- and mitochondrial-encoded proteomes for Arabidopsis with PeptideAtlas

This study identifies and analyzes RNA editing sites in plastid and mitochondrial proteomes of Arabidopsis using mass spectrometry data from PeptideAtlas.

Mapping the Arabidopsis thaliana proteome in PeptideAtlas and the nature of the unobserved (dark) proteome; strategies towards a complete proteome

This paper updates the Arabidopsis thaliana PeptideAtlas proteomics resource, identifies 78.6% of the predicted proteome, and uses a machine learning model to predict the dark proteome.

Conflict between short- and long-term experiences affects visual perception by modulating sensory or motor response system: evidence from Bayesian inference models

The paper investigates how conflict between short- and long-term experiences affects visual perception using Bayesian inference models and finds that it modulates sensory or motor response systems.

RFP-CyanineDye Probe Pair for In vivo Neurovascular Multiphoton Imaging

The paper introduces a fluorescence probe pair for in vivo neurovascular imaging, enabling simultaneous labeling of neurons and blood vessels with improved signal strength and depth penetration.

Establishment and Evaluation of Rat Models of Cervical Spondylopathy with Yin Deficiency Syndrome

This study establishes and evaluates rat models of cervical spondylopathy with Yin deficiency syndrome through sleep deprivation and behavioral assessments.

Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of skeletal muscle.

This study identifies Sox11 as a marker of differentiating muscle satellite cells, showing reduced expression in quiescent and aged cells, but finds it dispensable for muscle development and regeneration.

Mass-immigration shapes the antibiotic resistome of wastewater treatment plants

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

Redefining hematopoietic progenitor cells and reforming the hierarchy of hematopoiesis

This study redefines hematopoietic progenitor cells and reformulates the hematopoiesis hierarchy using a transcriptional atlas, identifying key transcription factors and distinct lineage commitment processes.

Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

Pangenome-based dynamic trajectories of intracellular gene transfers in Poaceae unveil a high rate of unceasing integration and selective retention in Triticeae

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

Crossing-over decision landscape in maize

The paper investigates how crossover (CO) distribution in maize becomes U-shaped during meiosis, finding that chromatin state, not DNA methylation or sequence polymorphism, shapes the final CO landscape.