Adaptive mitochondrial regulation of the proteasome
T. Meul, K. Berschneider, S. Schmitt, C. H. Mayr, L. F. Mattner, H. B. Schiller, A. Yazgili, X. Wang, C. Lukas, C. Prehn, J. Adamski, E. Graf, T. Schwarzmayr, F. Perocchi, A. Kukat, , S. Meiners
This study shows mitochondrial dysfunction reduces 26S proteasome assembly and activity, which can be reversed by aspartate or pyruvate supplementation.
bioRxiv · Apr 7, 2020 · PreprintCell Biology