C. H. Mayr

The paper uses ex vivo perturbations on human lung slices combined with single-cell RNA-seq to study fibrogenesis, showing similarities to in vivo cell circuits and drug effects.

This study identifies fibroblast-derived extracellular vesicles containing SFRP1 that contribute to pulmonary fibrosis and suggests SFRP1 as a therapeutic target.

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.

This study shows mitochondrial dysfunction reduces 26S proteasome assembly and activity, which can be reversed by aspartate or pyruvate supplementation.