The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC
A. Javitt, M. D. Shmueli, M. P. Kramer, A. A. Kolodziejczyk, I. J. Cohen, I. Kamer, K. Litchfield, E. Bab-Dinitz, O. Zadok, V. Neiens, A. Ulman, L. Radomir, H. Wolf-Levy, A. Eisenberg-Lerner, A. Kacen, , Y. Merbl
This paper identifies PSME4 as a proteasome regulator that suppresses anti-tumor immunity in NSCLC by inhibiting immunoproteasome activity and antigen presentation.
bioRxiv · Oct 24, 2021 · PreprintCancer Biology