Author

A. Polyzos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

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Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Bartek· 2 shared P. Galanos· 2 shared A. Angelopoulou· 1 shared A. Georgakilas· 1 shared A. Kotsinas· 1 shared A. M. Fundichely· 1 shared A. Maya-Mendoza· 1 shared A. Papantonis· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

J. Bartek

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Author profile →

3 papers

Recent·Most cited

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

E. W. P. Wong, M. Sahin, R. Yang, U. Lee, Y. A. Zhan, R. Misra, F. Tomas, N. Alomran, A. Polyzos, C. J. Lee, T. Trieu, A. M. Fundichely, T. Wiesner, A. Rosowicz, S. Cheng, , P. Chi

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

bioRxiv · May 31, 2024 · PreprintCancer Biology

Genomic instability is an early event driving chromatin reorganization and escape from oncogene-induced senescence

C. Zampetidis, P. Galanos, A. Angelopoulou, Y. Zhu, T. Karamitros, N. Lagopati, R. Mirzazadeh, A. Polyzos, S. Garnerone, E. G. Gusmao, K. Sofiadis, D. E. Pefani, M. Demaria, N. Crosetto, A. Maya-Mendoza, , V. G. Gorgoulis

The paper identifies an early chromosomal inversion that enables escape from oncogene-induced senescence by activating BHLHE40 and promoting malignant transformation.

bioRxiv · Dec 20, 2020Cell Biology

Mutational signatures reveal the role of RAD52 in p53-independent p21 driven genomic instability

P. Galanos, G. Pappas, A. Polyzos, A. Kotsinas, I. Svolaki, N. Giakoumakis, C. Glytsou, I. Pateras, U. Swain, V. Souliotis, A. Georgakilas, N. Geacintov, L. Scorrano, C. Lukas, J. Lukas, , V. Gorgoulis

This study shows chronic p21WAF1/Cip1 expression causes genomic instability by suppressing DNA repair pathways, revealing Rad52 as a key player in this process.

bioRxiv · Sep 28, 2017Cancer Biology