Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer
S. A. Wani, S. Hussain, J. S. Gray, D. Nayak, H. Tang, L. M. Perez, M. D. Long, M. Siddappa, C. McCabe, L. Campbell, M. R. Freeman, M. J. Campbell
This study identifies RARγ's role in bookmarking AR enhancer interactions in prostate cancer, showing its impact on enzalutamide sensitivity and lineage plasticity.
bioRxiv · Dec 15, 2023 · PreprintCancer Biology