D. Xia

The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish

The study shows that the intestinal microbiome, specifically Cetobacterium somerae, inhibits viral infection in zebrafish via a TLR2-type I IFN signaling pathway.

Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination and Eimeria tenella challenge

This study uses multi-omics analysis to identify shifts in the chicken gastrointestinal ecosystem following vaccination and Eimeria tenella challenge, revealing distinct metabolic and microbial profiles associated with health, infection, and recovery.

Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

This study shows TSPO on mitochondria promotes microglial inflammasome activation by stabilizing NLR proteins, inhibiting mitophagy, and enhancing pro-inflammatory gene expression, leading to excitotoxicity.

Point mutations in Arf1 reveal cooperative effects of the N-terminal region and myristate for GTPase-activating protein catalytic activity

The paper investigates how point mutations in Arf1 affect its interaction with GAPs, revealing cooperative effects between the N-terminal region and myristate on catalytic activity.

Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9

This study identifies two novel heterodimers of ABCB5{beta} in melanoma using bioluminescence resonance energy transfer, co-immunoprecipitation, and proximity ligation assay.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Deep learning accurately quantifies plasma cell percentages on CD138-stained bone marrow samples

This paper develops a deep learning model to quantify plasma cell percentages in CD138-stained bone marrow samples, achieving high accuracy comparable to pathologists.

Development of coarse-grained model for a minimal stratum corneum lipid mixture

The paper develops a coarse-grained model for stratum corneum lipids and validates it through simulations showing structural differences in multilayer systems compared to bilayers.

Probing differences in gene essentiality between the human and animal adapted lineages of the Mycobacterium tuberculosis complex using TnSeq

This study compares gene essentiality between Mycobacterium bovis and Mycobacterium tuberculosis using transposon sequencing and CRISPRi, finding species-specific differences in essential genes and their functional roles.

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

Potential Early Rabies Infection Detected in Two Raccoon Cases by LN34 pan-lyssavirus real-time RT-PCR Assay in Pennsylvania

The paper identifies two early rabies infection cases in raccoons using LN34 RT-qPCR, showing higher viral levels in caudal brain regions and confirming low-level infections.

Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

This study identifies Cavin4's role in T-tubule formation and stability in skeletal muscle by showing its interaction with Bin1 and effects on caveolae remodeling.