Author

A. Tang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 2 Bioengineering· 2 Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 14 Research Focus:cell type annotation· 8 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Organism:mouse· 3

Frequent Co-Authors

G. Coaker· 2 shared J. Tang· 2 shared J. Yang· 2 shared J. Zhu· 2 shared L. Li· 2 shared A. Afasizheva· 1 shared A. Aggarwal· 1 shared A. Asfaw· 1 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPlant Biology

G. Coaker

Mutual co-authors in cluster

Author profile →

17 papers

Recent·Most cited

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

W. Du, B. Zhou, A. Forjaz, S. M. Shin, F. Wu, A. J. Crawford, P. R. Nair, A. C. Johnston, H. West-Foyle, A. Tang, D. Kim, R. Fan, A. L. Kiemen, P.-H. Wu, J. M. Phillip, , D. Wirtz

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

bioRxiv · Jul 16, 2024 · PreprintImmunology

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

L. C. Foerster, O. Kaya, V. Wust, D.-P. Danciu, M. Bekavac, K. C. Ziegler, V. Akcay, N. Stinchcombe, A. Tang, J. Tang, J. Brunken, N. Gesteira Perez, X. Ma, A. Sadik, C. Opitz, , A. Martin-Villalba

This study identifies SFRP1 as a therapeutic target for glioblastoma by revealing its role in reprogramming tumor methylomes and improving survival in mouse models.

bioRxiv · Sep 15, 2023Cancer Biology

Optimization of RNA Pepper sensors for the detection of arbitrary RNA targets

A. Tang, A. Afasizheva, C. Cano, K. Plath, D. L. Black, E. Franco

This paper develops and optimizes Pepper RNA sensors for detecting arbitrary RNA targets with high brightness and sensitivity.

bioRxiv · Jun 1, 2023Biochemistry

Novel inhibitors against COVID-19 main protease suppressed viral infection

V. Ramachandran, Y. Liu, Q. He, A. Tang, P. Ronaldson, D. Schenten, R. Chang

This study identifies novel small-molecule inhibitors of SARS-CoV-2 main protease that suppress viral replication in human cells.

bioRxiv · Nov 5, 2022 · PreprintPathology

Single-cell profiling of complex plant responses to Pseudomonas syringae infection

J. Zhu, S. Lolle, A. Tang, B. Guel, B. Kvikto, B. Cole, G. Coaker

The paper profiles single-cell RNA sequencing data from Arabidopsis infected with Pseudomonas syringae to identify immune and susceptible cell clusters and their transcriptional responses.

bioRxiv · Oct 7, 2022 · PreprintPlant Biology

SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice

A. Tang, D. W. Buccholz, K. Szigety, B. Imbhiaka, S. Gao, M. Frankfurter, M. Wang, J. Yang, P. Hewins, P. Mericko-Ishizuka, N. Leu, S. Sterling, I. Monreal, J. Sahler, A. August, , M. Kahn

bioRxiv · Dec 4, 2021 · PreprintMicrobiology

A genetic toolkit for investigating Clavibacter: markerless deletion, permissive site identification and an integrative plasmid

D. Stevens, A. Tang, G. Coaker

This paper develops genetic tools for Clavibacter, including a markerless deletion system, an integrative plasmid, and an R package for identifying permissive integration sites.

bioRxiv · Jul 13, 2021Microbiology

Structural basis for HCMV Pentamer recognition by antibodies and neuropilin 2

D. Wrapp, X. Ye, Z. Ku, H. Su, H. G. Jones, N. Wang, A. K. Mishra, D. C. Freed, F. Li, A. Tang, L. Li, D. K. Jaijyan, H. Zhu, D. Wang, T.-M. Fu, , J. S. McLellan

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

bioRxiv · Mar 25, 2021 · PreprintMicrobiology

Miniaturizing wet scrubbers for aerosolized droplet capture

U. N. Lee, T. L. van Neel, F. Y. Lim, J. W. Khor, J. He, R. S. Vaddi, A. Q. Ong, A. Tang, J. Berthier, J. S. Meschke, I. V. Novosselov, A. B. Theberge, E. Berthier

The paper develops a miniaturized aerosol sampling device inspired by wet scrubbers, demonstrating efficient aerosol capture and viability retention of bioaerosols.

bioRxiv · Mar 23, 2021Bioengineering

Nurturing Diversity and Inclusion in AI in Biomedicine through a Virtual Summer Program for High School Students

T. Oskotsky, R. Bajaj, J. Burchard, T. B. Cavazos, I. Chen, W. Connell, S. Eaneff, T. Grant, I. Kanungo, K. Lindquist, D. J. Myers-Turnbull, Z. Z. C. Naing, A. Tang, B. Vora, J. X. Wang, , M. Sirota

The paper describes a virtual summer program for high school students aimed at increasing diversity in AI through biomedical education, showing improved knowledge and engagement in AI concepts.

bioRxiv · Mar 6, 2021Scientific Communication & Education

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

A. Ashhurst, A. Tang, P. Fajtova, M. Yoon, A. Aggarwal, A. Stoye, M. Larance, L. Beretta, A. Drelich, D. Skinner, L. Li, T. Meek, J. McKerrow, V. Hook, C.-T. Tseng, , R. J. Payne

bioRxiv · Dec 23, 2020 · PreprintBiochemistry

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

D. P. Bondeson, B. R. Paolella, A. Asfaw, M. Rothberg, T. Skipper, C. Langan, A. Gonzalez, L. Surface, K. Ito, M. Kazachkova, W. N. Colgan, A. Warren, J. Dempster, J. M. Krill-Burger, M. Ericcson, , T. R. Golub

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

bioRxiv · Oct 16, 2020Cancer Biology

Nucleolin is essential for rabbit hemorrhagic disease virus replication by providing a physical link in replication complex formation

J. Zhu, Q. Miao, H. Guo, R. Qi, A. Tang, D. Dong, J. Tang, G. Tong, G. Liu

This study identifies nucleolin as essential for RHDV replication by facilitating the formation of replication complexes through interactions with viral proteins.

bioRxiv · May 13, 2020 · PreprintMicrobiology

Antibiotic hypersensitivity signatures identify targets for attack in the Acinetobacter baumannii cell envelope

E. Geisinger, N. J. Mortman, Y. Dai, M. Cokol, S. Syal, A. Farinha, D. Fisher, A. Tang, D. W. Lazinski, S. Wood, J. Anthony, T. Opijnen, R. R. Isberg

This study identifies antibiotic hypersensitivity signatures in A. baumannii to discover new targets for attacking the pathogen's cell envelope.

bioRxiv · Mar 11, 2020Microbiology

Multi-ATOM: Ultrahigh-throughput single-cell quantitative phase imaging with subcellular resolution

K. Lee, A. Lau, A. Tang, M. Wnag, A. Mok, B. Chung, W. Yan, H. C. Shum, K. Cheah, G. Chan, H. So, K. Wong, K. Tsia

The paper introduces multi-ATOM, a high-throughput QPI method that enables subcellular resolution and accurate cell-type classification without compromising speed or quality.

bioRxiv · Jan 3, 2019Bioengineering

Potential PGPR properties of cellulolytic, nitrogen-fixing, and phosphate-solubilizing bacteria of a rehabilitated tropical forest soil

A. Tang, A. O. Haruna, N. M. Ab. Majid

This study isolates and characterizes cellulolytic, nitrogen-fixing, and phosphate-solubilizing bacteria from rehabilitated tropical forest soils to assess their potential plant growth-promoting properties.

bioRxiv · Jun 20, 2018Microbiology

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

P. De Jager, Y. Ma, C. McCabe, J. Xu, B. N. Vardarajan, D. Felsky, H.-U. Klein, C. C. White, M. A. Peters, B. Lodgson, P. Nejad, A. Tang, L. M. Mangravite, L. Yu, C. Gaiteri, , D. A. Bennett

The paper creates a multi-omic atlas of the human frontal cortex using data from aging and Alzheimer's studies, providing insights into brain biology and disease mechanisms.

bioRxiv · Jan 23, 2018Cell Biology