ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer
H. Schuhwerk, C. Menche, I. Armstark, P. Gupta, K. Fuchs, R. van Roey, M. H. Mosa, C. I. Geppert, S. Baerthel, D. Saur, F. R. Greten, S. Brabletz, T. Brabletz, H. F. Farin, M. P. Stemmler
This study shows that ZEB1 in cancer-associated fibroblasts suppresses anti-tumor immunity and promotes metastasis, and its loss increases immune checkpoint sensitivity.
bioRxiv · Mar 28, 2023Cancer Biology