Author

T. Brabletz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

M. P. Stemmler· 3 shared H. Schuhwerk· 2 shared I. Armstark· 2 shared K. Fuchs· 2 shared R. van Roey· 2 shared S. Brabletz· 2 shared B.-T. Preca· 1 shared C. Becker· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

M. P. Stemmler

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3 papers

Recent·Most cited

Macrophages foster adaptive anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction

K. Fuchs, I. Armstark, R. van Roey, Y. Hajjaj, E. D`Avanzo, R. Liguori, F. Ferrazzi, J. Ackermann, L. Amon, M. Alfredo, M. Faas, J. Huebner, M. H. Hoffmann, G. Kroenke, C. Becker, , H. Schuhwerk

This study identifies ZEB1 as a key regulator of TAM-mediated T cell trafficking, enhancing CTL recruitment and immunosurveillance in tumors and metastases.

bioRxiv · Feb 26, 2024Cancer Biology

ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

H. Schuhwerk, C. Menche, I. Armstark, P. Gupta, K. Fuchs, R. van Roey, M. H. Mosa, C. I. Geppert, S. Baerthel, D. Saur, F. R. Greten, S. Brabletz, T. Brabletz, H. F. Farin, M. P. Stemmler

This study shows that ZEB1 in cancer-associated fibroblasts suppresses anti-tumor immunity and promotes metastasis, and its loss increases immune checkpoint sensitivity.

bioRxiv · Mar 28, 2023Cancer Biology

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

M. K. Jolly, B.-T. Preca, S. C. Tripathi, D. Jia, S. M. Hanash, T. Brabletz, M. P. Stemmler, J. Maurer, H. Levine

The paper identifies interconnected feedback loops among ESRP1, HAS2, and CD44 that regulate ZEB1 levels and drive epithelial-hybrid-mesenchymal transition in cancer, with ESRP1 as a key regulatory node.

bioRxiv · Feb 5, 2018Cancer Biology