Relative adrenal insufficiency is a risk factor and an endotype of sepsis - A proof of concept study to support a precision medicine approach for glucocorticoid sepsis therapy
C.-H. Wu, L. Guo, Q. Wang, X. Ye, C. Mineo, P. W. Shaul, X.-A. Li
This study establishes a relative adrenal insufficiency (RAI) animal model and shows that glucocorticoid (GC) therapy benefits RAI mice but harms non-RAI mice, supporting a precision medicine approach for sepsis treatment.
bioRxiv · Apr 16, 2020 · PreprintImmunology