Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma
J. H. Um, Y. Zheng, Q. Mao, C. Nam, H. Zhao, Y. W. Koh, S.-J. Shin, Y. M. Park, D. Lin
This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.
bioRxiv · Jun 28, 2024 · PreprintCancer Biology