Q. Mao

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma

This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.

Brochosomes as an antireflective camouflage coating for leafhoppers

This study identifies brochosomes as an anti-reflective nano-coating in leafhoppers, revealing their structural proteins and evolutionary origin.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

Highly sensitive quantification of carbon monoxide (CO) in vivo reveals a protective role of circulating hemoglobin in CO intoxication

This study develops a colorimetric assay to quantify CO in tissues and shows that circulating hemoglobin prevents CO accumulation, offering new therapeutic approaches for CO poisoning.

Anacardic acid protects against phenylephrine-induced mouse cardiac hypertrophy through JNK signaling-dependent regulation of histone acetylation

This study shows anacardic acid reduces PE-induced cardiac hypertrophy by inhibiting JNK signaling and HAT-mediated histone acetylation in mice.

Is microbial activity in tropical forests limited by phosphorus availability? Evidence from a tropical forest in China

This study investigates whether microbial activity in tropical forests is limited by phosphorus availability, finding that P addition increases soil respiration but suppresses litter decomposition due to organic carbon desorption.