M. Sheth

Epigenomic Analyses Identify FOXM1 As a Key Regulator of Anti-Tumor Immune Response in Esophageal Adenocarcinoma

This study identifies FOXM1 as an epigenetic regulator in EAC that suppresses anti-tumor immune responses by inhibiting CD8+ T cell infiltration and function.

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

This study shows that selective ERβ agonists reduce viability of ER+ breast cancer cells and suggest their potential as a therapeutic strategy when combined with ER blockade.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

This study develops a cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma, finding that dual inhibition of proteasome and CRM1 pathways induces synergistic cytotoxicity.

Comprehensive characterization of internal and cuticle surface microbiota of laboratory-reared F1 Anopheles albimanus originating from different sites

This paper characterizes the internal and cuticle surface microbiota of F1 Anopheles albimanus larvae and adults from different Guatemalan sites, showing geographical variation persists in larvae but not adults.

Pyrethroid exposure alters Anopheles albimanus microbiota and resistant mosquitoes harbor more insecticide-metabolizing bacteria

An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance