H. Zhao

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma

This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

Chemically induced cell plasticity enables the generation of high-fidelity embryo model

This paper develops a chemical-only method to generate high-fidelity embryo models by inducing cell plasticity in stem cells, resulting in embryo-like structures that recapitulate early developmental stages.

Embracing Uncertainty Reshapes the ETHYLENE INSENSITIVE2-Activated Ethylene Signaling Framework

The paper challenges the current model of ethylene signaling by showing EIN2 activation can occur independently of CTR1, ETP1/ETP2, and MHL1/MHL2, and reveals new interactions and regulatory mechanisms.

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathways

This study uses scRNA-seq to analyze murine osteosarcoma models and identifies Skp2's role in metastasis, genomic instability, and immune activation, revealing potential therapeutic targets.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Skeleton-forming responses of reef-building corals under ocean acidification

This study examines how four coral species form skeletons under acidified conditions, revealing diverse strategies and damage patterns.

Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Plant Accessible Tissue Clearing Solvent System (PATCSOS) for 3-D Imaging of Whole Plants

The paper introduces PATCSOS, a new plant tissue clearing method enabling 3-D imaging of whole plants, including Arabidopsis tissues and other species, with high efficiency and compatibility with fluorescence imaging.

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity

This paper identifies a peptide, P92, that targets AbOmpA of A. baumannii, reducing bacterial pathogenicity without inhibiting growth, showing efficacy in multiple infection models.

Development of alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell derived liver organoids

This study develops a human induced pluripotent stem cell-derived liver organoid model of alcoholic liver disease to evaluate drug treatments and replicate key pathological features.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

Identification of SEC61B as a novel regulator of calcium flux and platelet hyperreactivity in diabetes mellitus

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

Eukaryotic genomic data uncover an extensive host range of mirusviruses

This study identifies mirusvirus markers in eukaryotic genomes, revealing a broader host range and greater diversity than previously known.

CRISPR-repressed toxin-antitoxin provides population-level immunity against diverse anti-CRISPR elements

The paper identifies a CRISPR-repressed toxin that provides population-level immunity against diverse anti-CRISPR elements by expelling them through abortive infection-like effects.

Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2

The paper examines how mutations in SARS-CoV-2 nucleocapsid protein's intrinsically disordered regions affect its biophysical properties across different variants.

Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides

The paper identifies lipoavitides, a novel class of RiPP/fatty acid hybrid lipopeptides with a unique HMP modification, and describes their biosynthetic pathway.

ASCT2 is the primary serine transporter in cancer cells

This study identifies ASCT2 as the primary serine transporter in cancer cells and shows its role in purine biosynthesis and therapeutic targeting.

YY2/BUB3 axis-mediated SAC hyperactivity determines tumor cell fate through chromosomal instability

This study identifies the YY2/BUB3 axis as a regulator of SAC activity and shows how SAC hyperactivity and CIN levels influence tumor cell fate and drug sensitivity.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

This study identifies CDK6-driven cell cycle acceleration in endothelial cells as a driver of arteriovenous malformations in HHT, suggesting CDK4/6 inhibitors as potential therapeutic options.